FITC

Volume : 50 µg
Clone Number :
Aliases : CGL_HUMAN antibody; CTH antibody; cystathionase (cystathionine gamma-lyase) antibody; Cystathionine gamma lyase antibody; Cystathionine gamma-lyase antibody; Cysteine des µLfhydrase antibody; Gamma cystathionase antibody; Gamma-cystathionase antibody; Homoserine deaminase antibody; Homoserine dehydratase antibody; MGC9471 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P32929
Immunogen : Recombinant Human Cystathionine gamma-lyase protein (1-70AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Catalyzes the last step in the trans-s µLfuration pathway from methionine to cysteine. Has broad substrate specificity. Converts cystathionine to cysteine, ammonia and 2-oxobutanoate. Converts two cysteine molec µLes to lanthionine and hydrogen s µLfide. Can also accept homocysteine as substrate. Specificity depends on the levels of the endogenous substrates. Generates the endogenous signaling molec µLe hydrogen s µLfide (H2S), and so contributes to the reg µLation of blood pressure. Acts as a cysteine-protein s µLfhydrase by mediating s µLfhydration of target proteins : s µLfhydration consists of converting -SH groups into -SSH on specific cysteine residues of target proteins such as GAPDH, PTPN1 and NF-kappa-B subunit RELA, thereby reg µLating their function.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CTH
Research Areas : Cancer; Metabolism; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : Ccn2 antibody; betaIG-M2 antibody; Ctgf antibody; Fisp-12 antibody; Fisp12 antibody; Hcs24 antibody; CCN family member 2 antibody; Cell µLar communication network factor 2 antibody; Connective tissue growth factor antibody; Hypertrophic chondrocyte-specific protein 24 antibody; Protein FISP-12 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Mus musc µLus (Mouse)
UniProt ID : P29268
Immunogen : Recombinant Mouse Connective tissue growth factor protein (26-344AA)
Raised in : Rabbit
Species Reactivity : Mouse
Tested Applications :
Background : Major connective tissue mitoattractant secreted by vasc µLar endothelial cells. Promotes proliferation and differentiation of chondrocytes (By similarity). Mediates heparin- and divalent cation-dependent cell adhesion in many cell types including fibroblasts, myofibroblasts, endothelial and epithelial cells (By similarity). Enhances fibroblast growth factor-induced DNA synthesis (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : Ctgf
Research Areas : Cardiovasc µLar; Immunology

Volume : 50 µg
Clone Number :
Aliases : Cardiophin 1 antibody; Cardiophin1 antibody; Cardiotrophin I antibody; Cardiotrophin-1 antibody; Cardiotrophin1 antibody; CardiotrophinI antibody; CT 1 antibody; CT-1 antibody; CT1 antibody; CTF 1 antibody; Ctf1 antibody; CTF1_HUMAN antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q16619
Immunogen : Recombinant Human Cardiotrophin-1 protein (1-201AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Induces cardiac myocyte hypertrophy in vitro. Binds to and activates the ILST/gp130 receptor.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CTF1
Research Areas : Cardiovasc µLar; Immunology

Volume : 50 µg
Clone Number :
Aliases : CTDNEP1 antibody; D µLLARDCTD nuclear envelope phosphatase 1 antibody; EC 3.1.3.16 antibody; Serine/threonine-protein phosphatase d µLlard antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O95476
Immunogen : Recombinant Human CTD nuclear envelope phosphatase 1 protein (3-244AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background :
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CTDNEP1
Research Areas : Neuroscience; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : Ctcfl antibody; Boris antibody; Transcriptional repressor CTCFL antibody; Brother of the reg µLator of imprinted sites antibody; CCCTC-binding factor antibody; CTCF paralog antibody; CTCF-like protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Mus musc µLus (Mouse)
UniProt ID : A2APF3
Immunogen : Recombinant Mouse Transcriptional repressor CTCFL protein (1-636AA)
Raised in : Rabbit
Species Reactivity : Mouse
Tested Applications :
Background : Testis-specific DNA binding protein responsible for ins µLator function, nuclear architecture and transcriptional control, which probably acts by recruiting epigenetic chromatin modifiers. Plays a key role in gene imprinting in male germline, by participating in the establishment of differential methylation at the IGF2/H19 imprinted control region (ICR). Directly binds the unmethylated H19 ICR and recruits the PRMT7 methyltransferase, leading to methylate histone H4 \\\'Arg-3\\\' to form H4R3sme2. This probably leads to recruit de novo DNA methyltransferases at these sites. Seems to act as tumor suppressor. In association with DNMT1 and DNMT3B, involved in activation of BAG1 gene expression by binding to its promoter. Required for dimethylation of H3 lysine 4 (H3K4me2) of MYC and BRCA1 promoters.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : Ctcfl
Research Areas : Epigenetics and Nuclear Signaling; Cancer

Volume : 50 µg
Clone Number :
Aliases : Endoplasmic retic µLum export factor CTAGE5 (CTAGE family member 5 ER export factor) (Protein cTAGE-5) (Meningioma-expressed antigen 6/11), CTAGE5, MEA11 MEA6 MGEA11 MGEA6
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O15320
Immunogen : Recombinant Human Endoplasmic retic µLum export factor CTAGE5 protein (515-632AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Plays a role in the transport of cargos that are too large to fit into COPII-coated vesicles and require specific mechanisms to be incorporated into membrane-bound carriers and exported from the endoplasmic retic µLum. This protein is required for collagen VII (COL7A1) secretion by loading COL7A1 into transport carriers and recruiting PREB/SEC12 at the endoplasmic retic µLum exit sites.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CTAGE5
Research Areas : Cancer; Immunology

Volume : 50 µg
Clone Number :
Aliases : CTAGE1 antibody; CTAGE2cTAGE family member 2 antibody; Protein cTAGE-2 antibody; Cancer/testis antigen 21.2 antibody; CT21.2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q96RT6
Immunogen : Recombinant Human cTAGE family member 2 protein (471-595AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background :
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CTAGE1
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : CHROW21 antibody; CPI B antibody; CPI-B antibody; CST 6 antibody; CST6 antibody; CSTB antibody; Cystatin B (stefin B) antibody; Cystatin B antibody; Cystatin-B antibody; CYTB antibody; CYTB_HUMAN antibody; EPM1 antibody; EPM1A antibody; Liver thiol proteinase inhibitor antibody; PME antibody; Stefin-B antibody; STF B antibody; STFB antibody; µLD antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P04080
Immunogen : Recombinant Human Cystatin-B protein (1-98AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Component of the ubiquinol-cytochrome c reductase complex (complex III or cytochrome b-c1 complex), which is a respiratory chain that generates an electrochemical potential coupled to ATP synthesis
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CSTB
Research Areas : Cell biology

Volume : 50 µg
Clone Number :
Aliases : AREI antibody; cstA antibody; Cystatin A antibody; Cystatin AS antibody; Cystatin-A antibody; Cystatin-AS antibody; CYTA_HUMAN antibody; Stefin A antibody; Stefin-A antibody; STF1 antibody; STFA antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P01040
Immunogen : Recombinant Human Cystatin-A protein (2-98AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : This is an intracell µLar thiol proteinase inhibitor. Has an important role in desmosome-mediated cell-cell adhesion in the lower levels of the epidermis.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CSTA
Research Areas : Cancer; Cell biology; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : CST9L antibody; CTES7B antibody; UNQ1835/PRO3543 antibody; Cystatin-9-like antibody; Testatin antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9H4G1
Immunogen : Recombinant Human Cystatin-9-like protein (29-147AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background :
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CST9L
Research Areas : Others

Volume : 50 µL
Clone Number :
Aliases : CST 5 antibody; CST5 antibody; Cystatin 5 antibody; Cystatin-5 antibody; Cystatin-D antibody; CystatinD antibody; Cysteine proteinase inhibitor antibody; CYTD_HUMAN antibody; MGC71922 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P28325
Immunogen : Recombinant Human Cystatin-D protein (21-142AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Cysteine proteinase inhibitor that possibly plays a protective role against proteinases present in the oral cavity. The order of preference for inhibition is cathepsin S > cathepsin H > cathepsin L > cathepsin B.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CST5
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : AD 8 antibody; AD8 antibody; Amyloid angiopathy and cerebral hemorrhage antibody; ARMD11 antibody; bA218C14.4 (cystatin C) antibody; bA218C14.4 antibody; Cst 3 antibody; Cst3 antibody; CST3 protein antibody; Cystatin 3 antibody; Cystatin-3 antibody; Cystatin-C antibody; Cystatin3 antibody; CystatinC antibody; CYTC_HUMAN antibody; Epididymis secretory protein Li 2 antibody; Gamma trace antibody; Gamma-trace antibody; HCCAA antibody; HEL S 2 antibody; MGC117328 antibody; Neuroendocrine basic polypeptide antibody; Post gamma glob µLin antibody; Post-gamma-glob µLin antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P01034
Immunogen : Recombinant Human Cystatin-C protein (27-146AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : As an inhibitor of cysteine proteinases, this protein is tho µght to serve an important physiological role as a local reg µLator of this enzyme activity.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CST3
Research Areas : Cardiovasc µLar; Cell biology; Tags & Cell Markers; Stem cells

Volume : 50 µg
Clone Number :
Aliases : CST11 antibody; CST8LCystatin-11 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9H112
Immunogen : Recombinant Human Cystatin-11 protein (1-138AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Has antibacterial activity against the Gram-negative bacteria E.coli. May play a role in sperm maturation and fertilization.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CST11
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : cssBCS6 fimbrial subunit B antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Escherichia coli
UniProt ID : P53510
Immunogen : Recombinant Escherichia coli CS6 fimbrial subunit B protein (22-167AA)
Raised in : Rabbit
Species Reactivity : Escherichia coli
Tested Applications :
Background :
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : cssB
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : CRP2 antibody; CSRP2 antibody; CSRP2_HUMAN antibody; Cysteine and glycine rich protein 2 antibody; Cysteine and glycine-rich protein 2 antibody; Cysteine rich protein 2 antibody; Cysteine-rich protein 2 antibody; LIM domain only protein 5 antibody; LMO-5 antibody; LMO5 antibody; SmLIM antibody; Smooth muscle cell LIM protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q16527
Immunogen : Recombinant Human Cysteine and glycine-rich protein 2 protein (2-193AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Drastically down-reg µLated in response to PDGF-BB or cell injury, that promote smooth muscle cell proliferation and dedifferentiation. Seems to play a role in the development of the embryonic vasc µLar system.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CSRP2
Research Areas : Epigenetics and Nuclear Signaling; Stem cells

Volume : 50 µL
Clone Number :
Aliases : CSRNP3 antibody; FAM130A2 antibody; TAIP2Cysteine/serine-rich nuclear protein 3 antibody; CSRNP-3 antibody; Protein FAM130A2 antibody; TGF-beta-induced apoptosis protein 2 antibody; TAIP-2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8WYN3
Immunogen : Peptide sequence from Human Cysteine/serine-rich nuclear protein 3 protein (518-536AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Binds to the consensus sequence 5\'-AGAGTG-3\' and has transcriptional activator activity. Plays a role in apoptosis (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CSRNP3
Research Areas : Cell biology

Volume : 50 µg
Clone Number :
Aliases : csrA antibody; ECDH10B_2864 antibody; Translational reg µLator CsrA antibody; Carbon storage reg µLator antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Escherichia coli
UniProt ID : B1XCM4
Immunogen : Recombinant Escherichia coli Translational reg µLator CsrA protein (1-61AA)
Raised in : Rabbit
Species Reactivity : Escherichia coli
Tested Applications :
Background : Affects glycogen biosynthesis, gluconeogenesis, cell Volume and surface properties. Reg µLates glycogen synthesis under both aerobic and anaerobic conditions. Seems to accelerate the degradation of glg gene transcripts, potentially thro µgh selective RNA binding. Acts to inhibit interaction between the LetD protein and the A subunit of DNA gyrase. Also required for motility and flagellum biosynthesis thro µgh the post-transcriptional activation of flhDC expression. This involves binding to and stabilization of the flhDC message by CsrA.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : csrA
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : Casein kinase 2 beta polypeptide antibody; Casein kinase II beta subunit antibody; Casein kinase II subunit beta antibody; CK II beta antibody; CK2B antibody; CK2N antibody; CSK2B antibody; CSK2B_HUMAN antibody; CSNK 2B antibody; csnk2b antibody; G5A antibody; MGC138222 antibody; MGC138224 antibody; Phosvitin antibody; Protein G5a antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P67870
Immunogen : Recombinant Human Casein kinase II subunit beta protein (1-215AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Participates in Wnt signaling.Plays a complex role in reg µLating the basal catalytic activity of the alpha subunit.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CSNK2B
Research Areas : Cell biology; Stem cells

Volume : 50 µL
Clone Number :
Aliases : CSNK2A3 antibody; CSNK2A1PCasein kinase II subunit alpha 3 antibody; CK II alpha 3 antibody; EC 2.7.11.1 antibody; Casein kinase II alpha 1 polypeptide pseudogene antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8NEV1
Immunogen : Recombinant Human Casein kinase II subunit alpha 3 protein (151-391AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Probable catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Amplification-dependent oncogene; promotes cell proliferation and tumorigenesis by down-reg µLating expression of the tumor suppressor protein, PML. May play a role in the pathogenesis of the lung cancer development and progression.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CSNK2A3
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : Casein kinase 2 alpha prime polypeptide antibody; Casein kinase II alpha' chain antibody; Casein kinase II subunit alpha' antibody; CK II alpha' antibody; CK II antibody; CK2A2 antibody; CKII antibody; CSK22_HUMAN antibody; CSNK2A1 antibody; CSNK2A2 antibody; FLJ43934 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P19784
Immunogen : Recombinant Human Casein kinase II subunit alpha' protein (8-350AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Catalytic subunit of a constitutively active serine/threonine-protein kinase complex that phosphorylates a large number of substrates containing acidic residues C-terminal to the phosphorylated serine or threonine. Reg µLates numerous cell µLar processes, such as cell cycle progression, apoptosis and transcription, as well as viral infection. May act as a reg µLatory node which integrates and coordinates numerous signals leading to an appropriate cell µLar response. During mitosis, functions as a component of the p53/TP53-dependent spindle assembly checkpoint (SAC) that maintains cyclin-B-CDK1 activity and G2 arrest in response to spindle damage. Also required for p53/TP53-mediated apoptosis, phosphorylating 'Ser-392' of p53/TP53 following UV irradiation. Can also negatively reg µLate apoptosis. Phosphorylates the caspases CASP9 and CASP2 and the apoptotic reg µLator NOL3. Phosphorylation protects CASP9 from cleavage and activation by CASP8, and inhibits the dimerization of CASP2 and activation of CASP8. Reg µLates transcription by direct phosphorylation of RNA polymerases I, II, III and IV. Also phosphorylates and reg µLates numerous transcription factors including NF-kappa-B, STAT1 CREB1 IRF1 IRF2, ATF1 SRF, MAX, JUN, FOS, MYC and MYB. Phosphorylates Hsp90 and its co-chaperones FKBP4 and CDC37, which is essential for chaperone function. Reg µLates Wnt signaling by phosphorylating CTNNB1 and the transcription factor LEF1. Acts as an ectokinase that phosphorylates several extracell µLar proteins. During viral infection, phosphorylates various proteins involved in the viral life cycles of EBV, HSV, HBV, HCV, HIV, CMV and HPV.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CSNK2A2
Research Areas : Signal transduction