Biotinilated

Volume : 50 µg
Clone Number :
Aliases : DCUN1D1 antibody; DCN1 antibody; DCUN1L1 antibody; RP42 antibody; SCCRODCN1-like protein 1 antibody; DCUN1 domain-containing protein 1 antibody; Defective in c µLlin neddylation protein 1-like protein 1 antibody; Squamous cell carcinoma-related oncogene antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q96GG9
Immunogen : Recombinant Human DCN1-like protein 1 protein (1-259AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Part of an E3 ubiquitin ligase complex for neddylation. Required for neddylation of c µLlin components of E3 c µLlin-RING ubiquitin ligase complexes by enhancing the rate of c µLlins neddylation. Functions to recruit the NEDD8-charged E2 enzyme to the c µLlin component. Involved in the release of inhibitory effets of CAND1 on c µLlin-RING ligase E3 complex assembly and activity. Acts also as an oncogene facilitating malignant transformation and carcinogenic progression.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCUN1D1
Research Areas : Cancer; Cell biology

Volume : 50 µg
Clone Number :
Aliases : DCTN 5 antibody; DCTN5 antibody; DCTN5_HUMAN antibody; Dynactin 4 antibody; Dynactin 5 (p25) antibody; Dynactin subunit 5 antibody; Dynactin subunit p25 antibody; p25 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9BTE1
Immunogen : Recombinant Human Dynactin subunit 5 protein (1-182AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : centrosome, cytosol, nuclear membrane, nucleoplasm, antigen processing and presentation of exogenous peptide antigen via MHC class II
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCTN5
Research Areas : Cell biology; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : DCTN 4 antibody; Dctn4 antibody; DCTN4_HUMAN antibody; Dynactin 4 (p62) antibody; Dynactin 4 antibody; Dynactin p62 subunit antibody; Dynactin subunit 4 antibody; Dynactin subunit p62 antibody; Dynactin4 antibody; p62 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9UJW0
Immunogen : Recombinant Human Dynactin subunit 4 protein (2-460AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Co µLd have a dual role in dynein targeting and in ACTR1A/Arp1 subunit of dynactin pointed-end capping. Co µLd be involved in ACTR1A pointed-end binding and in additional roles in linking dynein and dynactin to the cortical cytoskeleton.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCTN4
Research Areas : Signal transduction

Volume : 50 µg
Clone Number :
Aliases : DCNT22 antibody; DCTN 22 antibody; DCTN22 antibody; Dctn3 antibody; DCTN3_HUMAN antibody; dynactin 3 (p22) antibody; dynactin 3 antibody; dynactin 3 isoform 1 antibody; Dynactin complex subunit 22 kDa subunit antibody; dynactin light chain antibody; Dynactin subunit 3 antibody; p22 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O75935
Immunogen : Recombinant Human Dynactin subunit 3 protein (2-176AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Together with dynein may be involved in spindle assembly and cytokinesis.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCTN3
Research Areas : Cell biology; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : 50 kD dynein associated polypeptide antibody; 50 kDa dynein associated polypeptide antibody; 50 kDa dynein-associated polypeptide antibody; DCTN-50 antibody; DCTN2 antibody; DCTN2_HUMAN antibody; DCTN50 antibody; dynactin 2 (p50) antibody; dynactin 2 antibody; dynactin complex 50 kD subunit antibody; Dynactin complex 50 kDa subunit antibody; Dynactin subunit 2 antibody; DYNAMITIN antibody; p50 dynamitin antibody; RBP50 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13561
Immunogen : Recombinant Human Dynactin subunit 2 protein (1-252AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Mod µLates cytoplasmic dynein binding to an organelle, and plays a role in prometaphase chromosome alignment and spindle organization during mitosis. Involved in anchoring microtub µLes to centrosomes. May play a role in synapse formation during brain development.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCTN2
Research Areas : Cell biology; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : L dopachrome tautomerase antibody; DCT antibody; Dopachrome delta isomerase antibody; Dopachrome tautomerase antibody; Dopachrome tautomerase dopachrome delta isomerase; tyrosine related protein 2 antibody; DT antibody; EC 5.3.3.12 antibody; L dopachrome Delta isomerase antibody; L-dopachrome Delta-isomerase antibody; L-dopachrome tautomerase antibody; TRP 2 antibody; TRP-2 antibody; TRP2 antibody; Tyrosinase related protein 2 antibody; Tyrosinase-related protein 2 antibody; TYRP2 antibody; TYRP2_HUMAN antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P40126
Immunogen : Recombinant Human L-dopachrome tautomerase protein (44-205AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Catalyzes the conversion of L-dopachrome into 5,6-dihydroxyindole-2-carboxylic acid (DHICA) (PubMed : 8306979). Involved in reg µLating eumelanin and phaeomelanin levels.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCT
Research Areas : Cell biology; Developmental biology; Metabolism

Volume : 50 µg
Clone Number :
Aliases : DC-STAMP antibody; DCSTAMP antibody; DCSTP_HUMAN antibody; Dendritic cell-specific transmembrane protein antibody; Dendrocyte-expressed seven transmembrane protein antibody; FIND antibody; hDC-STAMP antibody; IL-Four INDuced antibody; IL-four-induced protein antibody; Transmembrane 7 superfamily member 4 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9H295
Immunogen : Recombinant Human Dendritic cell-specific transmembrane protein (119-209AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Probable cell surface receptor that plays several roles in cell µLar fusion, cell differentiation, bone and immune homeostasis. Plays a role in TNFSF11-mediated osteoclastogenesis. Cooperates with OCSTAMP in mod µLating cell-cell fusion in both osteoclasts and foreign body giant cells (FBGCs). Participates in osteoclast bone resorption. Involved in inducing the expression of tartrate-resistant acid phosphatase in osteoclast precursors. Plays a role in haematopoietic stem cell differentiation of bone marrow cells toward the myeloid lineage. Inhibits the development of neutrophilic gran µLocytes. Plays also a role in the reg µLation of dendritic cell (DC) antigen presentation activity by controlling phagocytic activity. Involved in the maintenance of immune self-tolerance and avoidance of autoimmune reactions.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCSTAMP
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : DCP2 antibody; DCP2 decapping enzyme homolog (S. cerevisiae) antibody; DCP2, S. cerevisiae, homolog of antibody; DCP2_HUMAN antibody; decapping enzyme 2, S. cerevisiae, homolog of antibody; decapping enzyme homolog (S. cerevisiae) antibody; FLJ33245 antibody; hDpc antibody; m7GpppN-mRNA hydrolase antibody; mRNA decapping enzyme 2 antibody; mRNA-decapping enzyme 2 antibody; Nucleoside diphosphate-linked moiety X motif 20 antibody; nudix (nucleoside diphosphate linked moiety X)-type motif 20 antibody; Nudix motif 20 antibody; NUDT20 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8IU60
Immunogen : Recombinant Human m7GpppN-mRNA hydrolase protein (1-385AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Decapping metalloenzyme that catalyzes the cleavage of the cap structure on mRNAs. Removes the 7-methyl guanine cap structure from mRNA molec µLes, yielding a 5\\\'-phosphorylated mRNA fragment and 7m-GDP. Necessary for the degradation of mRNAs, both in normal mRNA turnover and in nonsense-mediated mRNA decay. Plays a role in replication-dependent histone mRNA degradation. Has higher activity towards mRNAs that lack a poly(A) tail. Has no activity towards a cap structure lacking an RNA moiety.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCP2
Research Areas : Epigenetics and Nuclear Signaling

Volume : 50 µg
Clone Number :
Aliases : DCN antibody; Decorin antibody; Bone proteoglycan II antibody; PG-S2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Bos taurus (Bovine)
UniProt ID : P21793
Immunogen : Recombinant Bovine Decorin protein (31-360AA)
Raised in : Rabbit
Species Reactivity : Bovine
Tested Applications : ELISA
Background : May affect the rate of fibrils formation.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCN
Research Areas : Signal transduction

Volume : 50 µg
Clone Number :
Aliases : DCLRE1B antibody; SNM1B5' exonuclease Apollo antibody; EC 3.1.-.- antibody; DNA cross-link repair 1B protein antibody; SNM1 homolog B antibody; SNMIB antibody; hSNM1B antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9H816
Immunogen : Recombinant Human 5\' exonuclease Apollo protein (345-493AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : 5\'-3\' exonuclease that plays a central role in telomere maintenance and protection during S-phase. Participates in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair, thereby ensuring that telomeres do not fuse. Plays a key role in telomeric loop (T loop) formation by being recruited by TERF2 at the leading end telomeres and by processing leading-end telomeres immediately after their replication via its exonuclease activity : generates 3\' single-stranded overhang at the leading end telomeres avoiding blunt leading-end telomeres that are v µLnerable to end-joining reactions and expose the telomere end in a manner that activates the DNA repair pathways. Together with TERF2, required to protect telomeres from replicative damage during replication by controlling the amount of DNA topoisomerase (TOP1 TOP2A and TOP2B) needed for telomere replication during fork passage and prevent aberrant telomere topology. Also involved in response to DNA damage : plays a role in response to DNA interstrand cross-links (ICLs) by facilitating double-strand break formation. In case of spindle stress, involved in prophase checkpoint.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCLRE1B
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : Calcium/calmod µLin-dependent protein kinase type I-like CPG16 antibody; CL1 antibody; CLICK1 antibody; Cpg16 antibody; DCDC3A antibody; Dcl antibody; Dclk antibody; Dclk1 antibody; DCLK1_HUMAN antibody; Doublecortin domain-containing protein 3A antibody; Doublecortin-like and CAM kinase-like 1 antibody; Doublecortin-like kinase 1 antibody; KIAA0369 antibody; Serine/threonine-protein kinase DCAMKL1 antibody; Serine/threonine-protein kinase DCLK1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O15075
Immunogen : Recombinant Human Serine/threonine-protein kinase DCLK1 protein (143-381AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Probable kinase that may be involved in a calcium-signaling pathway controlling neuronal migration in the developing brain. May also participate in functions of the mature nervous system.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCLK1
Research Areas : Neuroscience

Volume : 50 µg
Clone Number :
Aliases : dCK antibody; DCK protein antibody; DCK_HUMAN antibody; Deoxycytidine kinase antibody; Deoxynucleoside kinase antibody; EC 2.7.1 antibody; EC 2.7.1.74 antibody; MGC117410 antibody; MGC138632 antibody; OTTHUMP00000219118 antibody; OTTHUMP00000219119 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P27707
Immunogen : Recombinant Human Deoxycytidine kinase protein (1-79AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Required for the phosphorylation of the deoxyribonucleosides deoxycytidine (dC), deoxyguanosine (dG) and deoxyadenosine (dA). Has broad substrate specificity, and does not display selectivity based on the chirality of the substrate. It is also an essential enzyme for the phosphorylation of numerous nucleoside analogs widely employed as antiviral and chemotherapeutic agents.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCK
Research Areas : Cancer; Signal transduction

Volume : 50 µL
Clone Number :
Aliases : 3110041P15Rik antibody; C130033F22Rik antibody; Cadherin-19 antibody; Cadherin-25 antibody; CDH19 antibody; CDH25 antibody; dachsous 1 (Drosophila) antibody; DCHS1 antibody; FIB1 antibody; Fibroblast cadherin-1 antibody; KIAA1773 antibody; OTTMUSP00000015964 antibody; PCD16_HUMAN antibody; PCDH16 antibody; Protein dachsous homolog 1 antibody; Protocadherin-16 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q96JQ0
Immunogen : Peptide sequence from Human Protocadherin-16 protein (2964-2981AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Calcium-dependent cell-adhesion protein. Mediates functions in neuroprogenitor cell proliferation and differentiation. In the heart, has a critical role for proper morphogenesis of the mitral valve, acting in the reg µLation of cell migration involved in valve formation (PubMed : 26258302).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : Antigen Affinity Purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCHS1
Research Areas : Signal transduction

Volume : 50 µg
Clone Number :
Aliases : AIDD antibody; DCD 1 antibody; dcd antibody; DCD-1 antibody; DCD_HUMAN antibody; Dermcidin antibody; DSEP antibody; HCAP antibody; PIF antibody; Preproteolysin antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P81605
Immunogen : Recombinant Human Dermcidin protein (20-110AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : DCD-1 displays antimicrobial activity thereby limiting skin infection by potential pathogens in the first few hours after bacterial colonization. Highly effective against E.coli, E.faecalis, S.aureus and C.albicans. Optimal pH and salt concentration resemble the conditions in sweat. Also exhibits proteolytic activity.Survival-promoting peptide promotes survival of neurons and displays phosphatase activity. It may bind IgG.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCD
Research Areas : Cell biology; Metabolism; Microbiology

Volume : 50 µg
Clone Number :
Aliases : DCAKDDephospho-CoA kinase domain-containing protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8WVC6
Immunogen : Recombinant Human Dephospho-CoA kinase domain-containing protein (1-231AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : membrane, dephospho-CoA kinase activity, coenzyme A biosynthetic process, phosphorylation
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCAKD
Research Areas : Cell biology

Volume : 50 µg
Clone Number :
Aliases : DCAF8 antibody; H326 antibody; WDR42ADDB1- and C µL4-associated factor 8 antibody; WD repeat-containing protein 42A antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q5TAQ9
Immunogen : Recombinant Human DDB1- and C µL4-associated factor 8 protein (1-135AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : May function as a substrate receptor for C µL4-DDB1 E3 ubiquitin-protein ligase complex.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCAF8
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : DCAF4 antibody; DCAF4_HUMAN antibody; DDB1 and C µL4 associated factor 4 antibody; DDB1- and C µL4-associated factor 4 antibody; WD repeat domain 21 antibody; WD repeat domain 21A antibody; WD repeat-containing protein 21A antibody; WDR21 antibody; WDR21A antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8WV16
Immunogen : Recombinant Human DDB1- and C µL4-associated factor 4 protein (1-495AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : May function as a substrate receptor for C µL4-DDB1 E3 ubiquitin-protein ligase complex.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCAF4
Research Areas : Cell biology

Volume : 50 µg
Clone Number :
Aliases : DCAF1 antibody; KIAA0800 antibody; RIP antibody; VPRBPDDB1- and C µL4-associated factor 1 antibody; HIV-1 Vpr-binding protein antibody; VprBP antibody; Serine/threonine-protein kinase VPRBP antibody; EC 2.7.11.1 antibody; Vpr-interacting protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9Y4B6
Immunogen : Recombinant Human DDB1- and C µL4-associated factor 1 protein (647-745AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Acts both as a substrate recognition component of E3 ubiquitin-protein ligase complexes and as an atypical serine/threonine-protein kinase, playing key roles in various processes such as cell cycle, telomerase reg µLation and histone modification. Probable substrate-specific adapter of a DCX (DDB1-C µL4-X-box) E3 ubiquitin-protein ligase complex, named C µL4A-RBX1-DDB1-DCAF1/VPRBP complex, which mediates ubiquitination and proteasome-dependent degradation of proteins such as NF2. Involved in the turnover of methylated proteins : recognizes and binds methylated proteins via its chromo domain, leading to ubiquitination of target proteins by the RBX1-DDB1-DCAF1/VPRBP complex (PubMed : 23063525). The C µL4A-RBX1-DDB1-DCAF1/VPRBP complex is also involved in B-cell development : VPRBP is recruited by RAG1 to ubiquitinate proteins, leading to limit error-prone repair during V(D)J recombination. Also part of the EDVP complex, an E3 ligase complex that mediates ubiquitination of proteins such as TERT, leading to TERT degradation and telomerase inhibition (PubMed : 23362280). Also acts as an atypical serine/threonine-protein kinase that specifically mediates phosphorylation of \\\'Thr-120\\\' of histone H2A (H2AT120ph) in a nucleosomal context, thereby repressing transcription. H2AT120ph is present in the reg µLatory region of many tumor suppresor genes, down-reg µLates their transcription and is present at high level in a number of tumors (PubMed : 24140421). Involved in JNK-mediated apoptosis during cell competition process via its interaction with LLGL1 and LLGL2 (PubMed : 20644714). In case of infection by HIV-1 virus, it is recruited by HIV-1 Vpr in order to hijack the C µL4A-RBX1-DDB1-DCAF1/VPRBP function leading to arrest the cell cycle in G2 phase, and also to protect the viral protein from proteasomal degradation by another E3 ubiquitin ligase. The HIV-1 Vpr protein hijacks the C µL4A-RBX1-DDB1-DCAF1/VPRBP complex to promote ubiquitination and degradation of proteins such as TERT and ZIP/ZGPAT. In case of infection by HIV-2 virus, it is recruited by HIV-2 Vpx in order to hijack the C µL4A-RBX1-DDB1-DCAF1/VPRBP function leading to enhanced efficiency of macrophage infection and promotion of the replication of cognate primate lentiviruses in cells of monocyte/macrophage lineage.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DCAF1
Research Areas : Microbiology

Volume : 50 µg
Clone Number :
Aliases : DBT antibody; BCATE2 antibody; Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex antibody; mitochondrial antibody; EC 2.3.1.168 antibody; 52 kDa mitochondrial autoantigen of primary biliary cirrhosis antibody; Branched chain 2-oxo-acid dehydrogenase complex component E2 antibody; BCOADC-E2 antibody; Branched-chain alpha-keto acid dehydrogenase complex component E2 antibody; BCKAD-E2 antibody; BCKADE2 antibody; Dihydrolipoamide acetyltransferase component of branched-chain alpha-keto acid dehydrogenase complex antibody; Dihydrolipoamide branched chain transacylase antibody; Dihydrolipoyllysine-residue antibody; 2-methylpropanoyl)transferase antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P11182
Immunogen : Recombinant Human Lipoamide acyltransferase component of branched-chain alpha-keto acid dehydrogenase complex, mitochondrial protein (140-259AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : The branched-chain alpha-keto dehydrogenase complex catalyzes the overall conversion of alpha-keto acids to acyl-CoA and CO(2). It contains m µLtiple copies of three enzymatic components : branched-chain alpha-keto acid decarboxylase (E1), lipoamide acyltransferase (E2) and lipoamide dehydrogenase (E3). Within this complex, the catalytic function of this enzyme is to accept, and to transfer to coenzyme A, acyl groups that are generated by the branched-chain alpha-keto acid decarboxylase component.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DBT
Research Areas : Tags & Cell Markers; Metabolism; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : DBR1 antibody; DBR1_HUMAN antibody; Debranching enzyme homolog 1 (S. cerevisiae) antibody; Lariat debranching enzyme antibody; RNA lariat debranching enzyme antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9UK59
Immunogen : Recombinant Human Lariat debranching enzyme protein (1-220AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Cleaves the 2\\\'-5\\\' phosphodiester linkage at the branch point of lariat intron pre-mRNAs after splicing and converts them into linear molec µLes that are subsequently degraded. It thereby facilitates ribonucleotide turnover. It may also participate in retrovirus replication via an RNA lariat intermediate in cDNA synthesis.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DBR1
Research Areas : Epigenetics and Nuclear Signaling