Volume : 50 µg
Clone Number :
Aliases : CPE-binding protein 3 antibody; CPE-BP3 antibody; CPEB 3 antibody; CPEB3 antibody; CPEB3_HUMAN antibody; Cytoplasmic polyadenylation element binding protein 3 antibody; Cytoplasmic polyadenylation element-binding protein 3 antibody; hCPEB-3 antibody; KIAA0940 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8NE35
Immunogen : Recombinant Human Cytoplasmic polyadenylation element-binding protein 3 protein (414-525AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications :
Background : Sequence-specific RNA-binding protein which acts as a translational repressor in the basal unstim µLated state but, following neuronal stim µLation, acts as a translational activator (By similarity). In contrast to CPEB1 does not bind to the cytoplasmic polyadenylation element (CPE), a uridine-rich sequence element within the mRNA 3\'-UTR, but binds to a U-rich loop within a stem-loop structure (By similarity). Required for the consolidation and maintenance of hippocampal-based long term memory (By similarity). In the basal state, binds to the mRNA 3\'-UTR of the glutamate receptors GRIA2/GLUR2 mRNA and negatively reg µLates their translation (By similarity). Also represses the translation of DLG4, GRIN1 GRIN2A and GRIN2B (By similarity). When activated, acts as a translational activator of GRIA1 and GRIA2 (By similarity). In the basal state, suppresses SUMO2 translation but activates it following neuronal stim µLation (By similarity). Binds to the 3\'-UTR of TRPV1 mRNA and represses TRPV1 translation which is required to maintain normal thermoception (By similarity). Binds actin mRNA, leading to actin translational repression in the basal state and to translational activation following neuronal stim µLation (By similarity). Negatively reg µLates target mRNA levels by binding to TOB1 which recruits CNOT7/CAF1 to a ternary complex and this leads to target mRNA deadenylation and decay (PubMed : 21336257). In addition to its role in translation, binds to and inhibits the transcriptional activation activity of STAT5B without affecting its dimerization or DNA-binding activity. This, in turn, represses transcription of the STAT5B target gene EGFR which has been shown to play a role in enhancing learning and memory performance (PubMed : 20639532). In contrast to CPEB1 CPEB2 and CPEB4, not required for cell cycle progression (PubMed : 26398195).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : FITC
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CPEB3
Research Areas : Neuroscience
