Volume : 50 µg
Clone Number :
Aliases : BBF-2 homolog antibody; CAMP responsive element binding protein 3 like 1 antibody; cAMP-responsive element-binding protein 3-like protein 1 antibody; CR3L1_HUMAN antibody; Creb3l1 antibody; Cyclic AMP responsive element binding protein 3 like protein 1 antibody; OASIS antibody; Old astrocyte specifically-induced substance antibody; Processed cyclic AMP-responsive element-binding protein 3-like protein 1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q96BA8
Immunogen : Recombinant Human Cyclic AMP-responsive element-binding protein 3-like protein 1 protein (396-500AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Transcription factor involved in unfolded protein response (UPR). In the absence of endoplasmic retic µLum (ER) stress, inserted into ER membranes, with N-terminal DNA-binding and transcription activation domains oriented toward the cytosolic face of the membrane. In response to ER stress, transported to the Golgi, where it is cleaved in a site-specific manner by resident proteases S1P/MBTPS1 and S2P/MBTPS2. The released N-terminal cytosolic domain is translocated to the nucleus to effect transcription of specific target genes. Plays a critical role in bone formation thro µgh the transcription of COL1A1 and possibly COL1A2, and the secretion of bone matrix proteins. Directly binds to the UPR element (UPRE)-like sequence in an osteoblast-specific COL1A1 promoter region and induces its transcription. Does not reg µLate COL1A1 in other tissues, such as skin (By similarity). Required to protect astrocytes from ER stress-induced cell death. In astrocytes, binds to the cAMP response element (CRE) of the BiP/HSPA5 promoter and participate in its transcriptional activation (By similarity). May play a role in limiting virus spread by inhibiting proliferation of virus-infected cells. Upon infection with diverse DNA and RNA viruses, inhibits cell-cycle progression by binding to promoters and activating transcription of genes encoding cell-cycle inhibitors, such as p21/CDKN1A (PubMed : 21767813). Binds the DNA consensus sequence 5\'-GTGXGCXGC-3\' (PubMed : 21767813).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : CREB3L1
Research Areas : Epigenetics and Nuclear Signaling; Signal transduction