Volume : 50 µg
Clone Number :
Aliases : Activin A receptor type 1B antibody; Activin A receptor type II like kinase 4 antibody; Activin A type 1B receptor antibody; Activin A type IB receptor antibody; Activin receptor like kinase 4 antibody; Activin receptor type 1B antibody; Activin receptor type IB antibody; Activin receptor type-1B antibody; Activin receptor-like kinase 4 antibody; ACTR IB antibody; ACTR-IB antibody; ACTRIB antibody; ACV1B_HUMAN antibody; ACVR 1B antibody; Acvr1b antibody; ACVRLK 4 antibody; ACVRLK4 antibody; ALK 4 antibody; ALK-4 antibody; ALK4 antibody; Serine(threonine) protein kinase receptor R2 antibody; Serine/threonine-protein kinase receptor R2 antibody; SKR 2 antibody; SKR2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P36896
Immunogen : Recombinant Human Activin receptor type-1B protein (150-300AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Transmembrane serine/threonine kinase activin type-1 receptor forming an activin receptor complex with activin receptor type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell surface to the cytoplasm and is thus reg µLating a many physiological and pathological processes including neuronal differentiation and neuronal survival, hair follicle development and cycling, FSH production by the pituitary gland, wound healing, extracell µLar matrix production, immunosuppression and carcinogenesis. Activin is also tho µght to have a paracrine or autocrine role in follic µLar development in the ovary. Within the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a primary activin receptors whereas the type-1 receptors like ACVR1B act as downstream transducers of activin signals. Activin binds to type-2 receptor at the plasma membrane and activates its serine-threonine kinase. The activated receptor type-2 then phosphorylates and activates the type-1 receptor such as ACVR1B. Once activated, the type-1 receptor binds and phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the C-terminal tail. Soon after their association with the activin receptor and subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm where they interact with the common partner SMAD4. This SMAD complex translocates into the nucleus where it mediates activin-induced transcription. Inhibitory SMAD7, which is recruited to ACVR1B thro µgh FKBP1A, can prevent the association of SMAD2 and SMAD3 with the activin receptor complex, thereby blocking the activin signal. Activin signal transduction is also antagonized by the binding to the receptor of inhibin-B via the IGSF1 inhibin coreceptor. ACVR1B also phosphorylates TDP2.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : ACVR1B
Research Areas : Signal transduction; Stem cells