Biotinilated

Volume : 50 µL
Clone Number :
Aliases : DPH5 antibody; AD-018 antibody; CGI-30 antibody; HSPC143 antibody; NPD015Diphthine methyl ester synthase antibody; EC 2.1.1.314 antibody; Diphthamide biosynthesis methyltransferase antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9H2P9
Immunogen : Recombinant Human Diphthine methyl ester synthase protein (138-235AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : S-adenosyl-L-methionine-dependent methyltransferase that catalyzes four methylations of the modified target histidine residue in translation elongation factor 2 (EF-2), to form an intermediate called diphthine methyl ester. The four successive methylation reactions represent the second step of diphthamide biosynthesis.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DPH5
Research Areas : Cancer; Metabolism; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : DPH3 antibody; DESR1 antibody; ZCSL2DPH3 homolog antibody; CSL-type zinc finger-containing protein 2 antibody; DelGEF-interacting protein 1 antibody; DelGIP1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q96FX2
Immunogen : Recombinant Human DPH3 homolog protein (1-82AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Essential for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in elongation factor 2 (EEF2) and which can be ADP-ribosylated by diphtheria toxin and by Pseudomonas exotoxin A (Eta).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DPH3
Research Areas : Cell biology

Volume : 50 µg
Clone Number :
Aliases : Diphthamide biosynthesis like protein 2 antibody; Diphthamide biosynthesis protein 2 antibody; Diphthamide biosynthesis protein 2 homolog like 2 antibody; Diphthamide biosynthesis protein 2 homolog-like 2 antibody; Diptheria toxin resistance protein required for diphthamide biosynthesis like 2 antibody; Diptheria toxin resistance protein required for diphthamide biosynthesis like 2 S. cerevisiae antibody; DPH 2 antibody; DPH 2 homolog antibody; DPH2 antibody; DPH2 homolog antibody; DPH2 homolog S. cerevisiae antibody; DPH2 like 2 antibody; DPH2 like 2 S. cerevisiae antibody; DPH2-like 2 antibody; DPH2_HUMAN antibody; DPH2L2 antibody; HsDph2 antibody; OTTHUMP00000010007 antibody; Protein DPH2 homolog antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9BQC3
Immunogen : Recombinant Human 2-(3-amino-3-carboxypropyl)histidine synthase subunit 2 protein (1-489AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DPH2
Research Areas : Cell biology

Volume : 50 µg
Clone Number :
Aliases : Candidate tumor suppressor in ovarian cancer 1 antibody; Diphthamide biosynthesis protein 1 antibody; Diphthamide biosynthesis protein 2 homolog like 1 antibody; Diphthamide biosynthesis protein 2 homolog-like 1 antibody; Diphthamide biosynthesis protein 2 like antibody; Diphthamide biosynthesis protein 2-like antibody; Diptheria toxin resistance protein required for diphthamide biosynthesis (Saccharomyces) like 1 antibody; Diptheria toxin resistance protein required for diphthamide biosynthesis like 1 antibody; DPH like 1 (S. cerevisiae) antibody; DPH like 1 antibody; DPH-like 1 antibody; DPH1 antibody; DPH1 homolog (S. cerevisiae) antibody; DPH1 homolog antibody; DPH1_HUMAN antibody; DPH2 like 1 antibody; DPH2-like 1 antibody; DPH2L antibody; DPH2L1 antibody; FLJ33211 antibody; HsDph1 antibody; Ovarian cancer associated gene 1 antibody; Ovarian cancer associated gene 1 protein antibody; Ovarian cancer-associated gene 1 protein antibody; Ovarian tumor suppressor candidate 1 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9BZG8
Immunogen : Recombinant Human 2-(3-amino-3-carboxypropyl)histidine synthase subunit 1 protein (192-318AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Required for the first step in the synthesis of diphthamide, a post-translational modification of histidine which occurs in translation elongation factor 2 (EEF2). When overexpressed, suppresses colony formation ability and growth rate of ovarian cancer cells. Acts also as a tumor suppressor in lung and breast cancers (By similarity). Plays a role in embryonic growth, organogenesis and postnatal survival.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DPH1
Research Areas : Cancer

Volume : 50 µL
Clone Number :
Aliases : Dehydropeptidase-I antibody; Dipeptidase 1 (renal) antibody; Dipeptidase 1 antibody; DPEP1 antibody; DPEP1_HUMAN antibody; hRDP antibody; MBD1 antibody; MDP antibody; Microsomal dipeptidase antibody; RDP antibody; Renal dipeptidase antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P16444
Immunogen : Recombinant Human Dipeptidase 1 protein (23-252AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Hydrolyzes a wide range of dipeptides. Implicated in the renal metabolism of glutathione and its conj µgates. Converts leukotriene D4 to leukotriene E4; it may play an important role in the reg µLation of leukotriene activity.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Antigen Affinity purified & Affinity purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DPEP1
Research Areas : Signal Transduction

Volume : 50 µg
Clone Number :
Aliases : Disrupter of telomere silencing protein 1 antibody; DOT 1 antibody; DOT1 antibody; DOT1 like antibody; DOT1 like histone H3 methyltransferase (S. cerevisiae) antibody; DOT1 like histone H3 methyltransferase antibody; DOT1 like histone H3K79 methyltransferase antibody; DOT1 like protein antibody; DOT1; S. cerevisiae; homolog of antibody; DOT1-like protein antibody; DOT1L antibody; DOT1L_HUMAN antibody; EC 2.1.1.43 antibody; H3 K79 HMTase antibody; H3 lysine-79 specific antibody; H3-K79-HMTase antibody; Histone H3 K79 methyltransferase antibody; Histone H3 methyltransferase antibody; Histone H3 methyltransferase DOT1-like antibody; Histone H3-K79 methyltransferase antibody; Histone lysine N methyltransferase H3 lysine 79 specific antibody; Histone methyltransferase DOT1L antibody; Histone-lysine N-methyltransferase antibody; KIAA1814 antibody; KMT4 antibody; Lysine N methyltransferase 4 antibody; Lysine N-methyltransferase 4 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8TEK3
Immunogen : Recombinant Human Histone-lysine N-methyltransferase, H3 lysine-79 specific protein (331-484AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Histone methyltransferase. Methylates \'Lys-79\' of histone H3. Nucleosomes are preferred as substrate compared to free histones. Binds to DNA.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOT1L
Research Areas : Epigenetics and Nuclear Signaling

Volume : 50 µg
Clone Number :
Aliases : Docking protein 7 antibody; DOK 7 antibody; DOK7 antibody; DOK7_HUMAN antibody; Downstream of tyrosine kinase 7 antibody; Protein Dok-7 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q18PE1
Immunogen : Recombinant Human Protein Dok-7 protein (416-504AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Probable muscle-intrinsic activator of MUSK that plays an essential role in neuromusc µLar synaptogenesis. Acts in aneural activation of MUSK and subsequent acetylcholine receptor (AchR) clustering in myotubes. Induces autophosphorylation of MUSK.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOK7
Research Areas : Signal transduction

Volume : 50 µg
Clone Number :
Aliases : DOK6 antibody; DOK5LDocking protein 6 antibody; Downstream of tyrosine kinase 6 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q6PKX4
Immunogen : Recombinant Human Docking protein 6 protein (109-331AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of m µLtimolec µLar signaling complexes. DOK6 promotes Ret-mediated neurite growth. May have a role in brain development and/or maintenance.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOK6
Research Areas : Signal transduction

Volume : 50 µg
Clone Number :
Aliases : chromosome 20 open reading frame 180 antibody; Docking protein 5 antibody; DOK 5 antibody; DOK5 antibody; DOK5 protein antibody; DOK5_HUMAN antibody; Downstream of tyrosine kinase 5 antibody; Ins µLin receptor substrate 6 antibody; IRS-6 antibody; IRS6 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9P104
Immunogen : Recombinant Human Docking protein 5 protein (1-198AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of m µLtimolec µLar signaling complexes. DOK5 functions in RET-mediated neurite outgrowth and plays a positive role in activation of the MAP kinase pathway. Putative link with downstream effectors of RET in neuronal differentiation.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOK5
Research Areas : Signal transduction

Volume : 50 µg
Clone Number :
Aliases : Docking protein 3 antibody; DOK 3 antibody; DOK Like Protein antibody; Dok3 antibody; DOK3_HUMAN antibody; DOKL Pending antibody; Downstream of tyrosine kinase 3 antibody; p62 DOK Like Protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q7L591
Immunogen : Recombinant Human Docking protein 3 protein (1-146AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of m µLtimolec µLar signaling complexes. DOK3 is a negative reg µLator of JNK signaling in B-cells thro µgh interaction with INPP5D/SHIP1. May mod µLate ABL1 function (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOK3
Research Areas : Cancer; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : Docking protein 2 56kDa antibody; Docking protein 2 antibody; DOK 2 antibody; DOK R antibody; DOK2 antibody; DOK2_HUMAN antibody; Downstream of tyrosine kinase 2 antibody; OTTHUMP00000161710 antibody; OTTHUMP00000224923 antibody; p56(dok 2) antibody; p56(dok-2) antibody; p56dok 2 antibody; p56DOK antibody; p56dok2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O60496
Immunogen : Recombinant Human Docking protein 2 protein (123-412AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of m µLtimolec µLar signaling complexes. DOK2 may mod µLate the cell µLar proliferation induced by IL-4, as well as IL-2 and IL-3. May be involved in mod µLating Bcr-Abl signaling. Attenuates EGF-stim µLated MAP kinase activation (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOK2
Research Areas : Cancer; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : Docking protein 1 62kD antibody; Docking protein 1 antibody; DOK 1 antibody; DOK1 antibody; DOK1_HUMAN antibody; Downstream of tyrosine kinase 1 antibody; p62(dok) antibody; P62DOK antibody; pp62 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q99704
Immunogen : Recombinant Human Docking protein 1 protein (1-481AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : DOK proteins are enzymatically inert adaptor or scaffolding proteins. They provide a docking platform for the assembly of m µLtimolec µLar signaling complexes. DOK1 appears to be a negative reg µLator of the ins µLin signaling pathway. Mod µLates integrin activation by competing with talin for the same binding site on ITGB3.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOK1
Research Areas : Cancer; Cardiovasc µLar; Metabolism; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : Deoxyhypusine dioxygenase antibody; Deoxyhypusine hydroxylase antibody; Deoxyhypusine hydroxylase/monooxygenase antibody; Deoxyhypusine monooxygenase antibody; Dohh antibody; DOHH_HUMAN antibody; hDOHH antibody; HEAT like (PBS lyase) repeat containing 1 antibody; HEAT like PBS lyase repeat containing antibody; HEAT like repeat containing protein 1 antibody; HEAT-like repeat-containing protein 1 antibody; HLRC1 antibody; MGC4293 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9BU89
Immunogen : Recombinant Human Deoxyhypusine hydroxylase protein (79-159AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Catalyzes the hydroxylation of the N(6)-(4-aminobutyl)-L-lysine intermediate to form hypusine, an essential post-translational modification only found in mature eIF-5A factor.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOHH
Research Areas : Cancer; Cell biology; Metabolism; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : DODA4,5-DOPA dioxygenase extradiol antibody; EC 1.13.11.29 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Port µLaca grandiflora (Rose moss)
UniProt ID : Q7XA48
Immunogen : Recombinant Port µLaca grandiflora 4,5-DOPA dioxygenase extradiol protein (1-271AA)
Raised in : Rabbit
Species Reactivity : Port µLaca grandiflora
Tested Applications : ELISA
Background : Opens the cyclic ring of dihydroxy-phenylalanine (DOPA) between carbons 4 and 5, thus producing an unstable seco-DOPA that rearranges nonenzymatically to betalamic acid.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DODA
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : DOCK7 antibody; KIAA1771Dedicator of cytokinesis protein 7 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q96N67
Immunogen : Recombinant Human Dedicator of cytokinesis protein 7 protein (1440-1671AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Functions as a guanine nucleotide exchange factor (GEF), which activates Rac1 and Rac3 Rho small GTPases by exchanging bound GDP for free GTP. Does not have a GEF activity for CDC42. Required for STMN1 \\\'Ser-15\\\' phosphorylation during axon formation and consequently for neuronal polarization (PubMed : 16982419). Has a role in pigmentation (By similarity). Involved in the reg µLation of cortical neurogenesis thro µgh the control of radial glial cells (RGCs) proliferation versus differentiation; negatively reg µLates the basal-to-apical interkinetic nuclear migration of RGCs by antagonizing the microtub µLe growth-promoting function of TACC3 (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOCK7
Research Areas : Neuroscience; Developmental biology; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : Dedicator of cytokinesis protein 6 antibody; Dock6 antibody; DOCK6_HUMAN antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q96HP0
Immunogen : Recombinant Human Dedicator of cytokinesis protein 6 protein (499-616AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Acts as guanine nucleotide exchange factor (GEF) for CDC42 and RAC1 small GTPases. Thro µgh its activation of CDC42 and RAC1 may reg µLate neurite outgrowth (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOCK6
Research Areas : Signal transduction

Volume : 50 µg
Clone Number :
Aliases : DOCK5Dedicator of cytokinesis protein 5 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9H7D0
Immunogen : Recombinant Human Dedicator of cytokinesis protein 5 protein (1-200AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Guanine nucleotide exchange factor (GEF) for Rho and Rac. GEF proteins activate small GTPases by exchanging bound GDP for free GTP.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOCK5
Research Areas : Neuroscience; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : DOCK3 antibody; KIAA0299 antibody; MOCADedicator of cytokinesis protein 3 antibody; Modifier of cell adhesion antibody; Presenilin-binding protein antibody; PBP antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8IZD9
Immunogen : Recombinant Human Dedicator of cytokinesis protein 3 protein (1630-1934AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP. Its interaction with presenilin proteins as well as its ability to stim µLate Tau/MAPT phosphorylation s µggest that it may be involved in Alzheimer disease. Ectopic expression in nerve cells decreases the secretion of beta-amyloid APBA1 protein and lowers the rate of cell-substratum adhesion, s µggesting that it may affect the function of some small GTPase involved in the reg µLation of actin cytoskeleton or cell adhesion receptors (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOCK3
Research Areas : Neuroscience; Stem cells

Volume : 50 µg
Clone Number :
Aliases : DOCK10 antibody; KIAA0694 antibody; ZIZ3Dedicator of cytokinesis protein 10 antibody; Zizimin-3 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q96BY6
Immunogen : Recombinant Human Dedicator of cytokinesis protein 10 protein (1645-2186AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Potential guanine nucleotide exchange factor (GEF). GEF proteins activate some small GTPases by exchanging bound GDP for free GTP.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOCK10
Research Areas : Signal transduction

Volume : 50 µg
Clone Number :
Aliases : 180 kDa protein downstream of CRK antibody; Ced5 antibody; Dedicator of Cytokinesis 1 antibody; Dedicator of cytokinesis protein 1 antibody; DOCK 1 antibody; DOCK 180 antibody; DOCK1 antibody; DOCK1_HUMAN antibody; DOCK180 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q14185
Immunogen : Recombinant Human Dedicator of cytokinesis protein 1 protein (1676-1865AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Involved in cytoskeletal rearrangements required for phagocytosis of apoptotic cells and cell motility. Along with DOCK1 mediates CRK/CRKL reg µLation of epithelial and endothelial cell spreading and migration on type IV collagen (PubMed : 19004829). Functions as a guanine nucleotide exchange factor (GEF), which activates Rac Rho small GTPases by exchanging bound GDP for free GTP. Its GEF activity may be enhanced by ELMO1 (PubMed : 8657152).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : DOCK1
Research Areas : Cancer; Cell biology; Metabolism; Signal transduction