Biotinilated

Volume : 50 µg
Clone Number :
Aliases : LCE2A antibody; LEP9Late cornified envelope protein 2A antibody; Late envelope protein 9 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q5TA79
Immunogen : Recombinant Human Late cornified envelope protein 2A protein (1-106AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Precursors of the cornified envelope of the stratum corneum.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LCE2A
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : Late cornified envelope protein 1B antibody; Late envelope protein 2 antibody; LCE1B antibody; LCE1B_HUMAN antibody; LEP2 antibody; Small proline-rich-like epidermal differentiation complex protein 2A antibody; SPRL2A antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q5T7P3
Immunogen : Recombinant Human Late cornified envelope protein 1B protein (1-118AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Precursors of the cornified envelope of the stratum corneum.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LCE1B
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : LCAT antibody; LCAT_HUMAN antibody; Lecithin cholesterol acyltransferase antibody; Lecithin-cholesterol acyltransferase antibody; Phosphatidylcholine sterol acyltransferase antibody; Phosphatidylcholine-sterol acyltransferase antibody; Phospholipid cholesterol acyltransferase antibody; Phospholipid-cholesterol acyltransferase antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P04180
Immunogen : Recombinant Human Phosphatidylcholine-sterol acyltransferase protein (25-433AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Central enzyme in the extracell µLar metabolism of plasma lipoproteins. SyntheVolumed mainly in the liver and secreted into plasma where it converts cholesterol and phosphatidylcholines (lecithins) to cholesteryl esters and lysophosphatidylcholines on the surface of high and low density lipoproteins (HDLs and LDLs). The cholesterol ester is then transported back to the liver. Has a preference for plasma 16 : 0-18 : 2 or 18 : O-18 : 2 phosphatidylcholines. Also produced in the brain by primary astrocytes, and esterifies free cholesterol on nascent APOE-containing lipoproteins secreted from glia and influences cerebral spinal fluid (CSF) APOE- and APOA1 levels. Together with APOE and the cholesterol transporter ABCA1 plays a key role in the maturation of glial-derived, nascent lipoproteins. Required for remodeling high-density lipoprotein particles into their spherical forms.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LCAT
Research Areas : Cancer; Cardiovasc µLar; Metabolism; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : LCA5 antibody; C6orf152Lebercilin antibody; Leber congenital amaurosis 5 protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q86VQ0
Immunogen : Recombinant Human Lebercilin protein (101-400AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Might be involved in minus end-directed microtub µLe transport.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LCA5
Research Areas : Neuroscience

Volume : 50 µg
Clone Number :
Aliases : BPI fold containing family D, member 2 antibody; Bpifd2 antibody; LBP antibody; LBP_HUMAN antibody; LBP1 antibody; Lipopolysaccharide binding protein antibody; Lipopolysaccharide-binding protein antibody; LPS binding protein antibody; Ly88 antibody; MGC22233 antibody; OTTHUMP00000030965 antibody; RP23-407H16.4 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : P18428
Immunogen : Recombinant Human Lipopolysaccharide-binding protein (304-414AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Plays a role in the innate immune response. Binds to the lipid A moiety of bacterial lipopolysaccharides (LPS), a glycolipid present in the outer membrane of all Gram-negative bacteria (PubMed : 7517398, PubMed : 24120359). Acts as an affinity enhancer for CD14, facilitating its association with LPS. Promotes the release of cytokines in response to bacterial lipopolysaccharide (PubMed : 7517398, PubMed : 24120359).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LBP
Research Areas : Immunology; Microbiology

Volume : 50 µg
Clone Number :
Aliases : hLBH antibody; lbh antibody; LBH_HUMAN antibody; Limb bud and heart development antibody; Limb bud and heart development homolog (mouse) antibody; Protein LBH antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q53QV2
Immunogen : Recombinant Human Protein LBH protein (1-105AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Transcriptional activator which may act in mitogen-activated protein kinase signaling pathway.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LBH
Research Areas : Epigenetics and Nuclear Signaling

Volume : 50 µL
Clone Number :
Aliases : Layilin antibody; LAYN antibody; LAYN_HUMAN antibody; UNQ208/PRO234 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q6UX15
Immunogen : Recombinant Human Layilin protein (262-382AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Receptor for hyaluronate.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LAYN
Research Areas : Signal Transduction

Volume : 50 µg
Clone Number :
Aliases : LAX1 antibody; LAX antibody; Lymphocyte transmembrane adapter 1 antibody; Linker for activation of X cells antibody; Membrane-associated adapter protein LAX antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q8IWV1
Immunogen : Recombinant Human Lymphocyte transmembrane adapter 1 protein (107-298AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Negatively reg µLates TCR (T-cell antigen receptor)-mediated signaling in T-cells and BCR (B-cell antigen receptor)-mediated signaling in B-cells.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LAX1
Research Areas : Immunology; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : Large tumor suppressor kinase 2, lats2
Product Type : polyclonal Ab Antibody
Immunogen Species : Zebrafish
UniProt ID : B0S8I4
Immunogen : Recombinant Zebrafish Large tumor suppressor kinase 2 protein (1022-1140AA)
Raised in : Rabbit
Species Reactivity : Zebrafish
Tested Applications : ELISA
Background :
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : lats2
Research Areas :

Volume : 50 µg
Clone Number :
Aliases : h-warts antibody; Large tumor suppressor homolog 1 antibody; LATS large tumor suppressor homolog 1 antibody; LATS1 antibody; LATS1_HUMAN antibody; Serine threonine protein kinase LATS1 antibody; Serine/threonine-protein kinase LATS1 antibody; WARTS antibody; WARTS protein kinase antibody; wts antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : O95835
Immunogen : Recombinant Human Serine/threonine-protein kinase LATS1 protein (1-280AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Negative reg µLator of YAP1 in the Hippo signaling pathway that plays a pivotal role in organ Volume control and tumor suppression by restricting proliferation and promoting apoptosis. The core of this pathway is composed of a kinase cascade wherein STK3/MST2 and STK4/MST1 in complex with its reg µLatory protein SAV1 phosphorylates and activates LATS1/2 in complex with its reg µLatory protein MOB1 which in turn phosphorylates and inactivates YAP1 oncoprotein and WWTR1/TAZ. Phosphorylation of YAP1 by LATS1 inhibits its translocation into the nucleus to reg µLate cell µLar genes important for cell proliferation, cell death, and cell migration. Acts as a tumor suppressor which plays a critical role in maintenance of ploidy thro µgh its actions in both mitotic progression and the G1 tetraploidy checkpoint. Negatively reg µLates G2/M transition by down-reg µLating CDK1 kinase activity. Involved in the control of p53 expression. Affects cytokinesis by reg µLating actin polymerization thro µgh negative mod µLation of LIMK1. May also play a role in endocrine function.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LATS1
Research Areas : Epigenetics and Nuclear Signaling; Cancer; Cell biology; Signal transduction

Volume : 50 µg
Clone Number :
Aliases : LASP 1 antibody; LASP-1 antibody; LASP1 antibody; LASP1_HUMAN antibody; LIM and SH3 domain protein 1 antibody; LIM and SH3 protein 1 antibody; Metastatic lymph node gene 50 protein antibody; MLN 50 antibody; MLN50 antibody; OTTHUMP00000164238 antibody; OTTHUMP00000164239 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q14847
Immunogen : Recombinant Human LIM and SH3 domain protein 1 protein (128-252AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Plays an important role in the reg µLation of dynamic actin-based, cytoskeletal activities. Agonist-dependent changes in LASP1 phosphorylation may also serve to reg µLate actin-associated ion transport activities, not only in the parietal cell but also in certain other F-actin-rich secretory epithelial cell types (By similarity).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LASP1
Research Areas : Signal transduction

Volume : 50 µg
Clone Number :
Aliases : lasA antibody; PA1871Protease LasA antibody; EC 3.4.24.- antibody; Staphylolytic protease antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Pseudomonas aer µginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1)
UniProt ID : P14789
Immunogen : Recombinant Pseudomonas aer µginosa Protease LasA protein (237-418AA)
Raised in : Rabbit
Species Reactivity : Pseudomonas aer µginosa
Tested Applications : ELISA
Background : Involved in proteolysis and elastolysis (degradation of the host protein elastin). Has staphylolytic activity (degrades pentaglycine cross-links in cell wall peptidogylcan), preferring Gly-Gly-|-X substrates where X is Ala or Gly (PubMed : 11179971). Enhances the elastolytic but not proteolytic activity of elastase (lasB) and elastolytic activity of other proteases (PubMed : 2110137). Degradation of host elastin is likely to contribute to the pathogenicity of P.aer µginosa. While either His-317 or His-356 can abstract a proton in the hydrolysis reaction, the same residue performs both functions in a given catalytic cycle, with the other stabilizing the catalytic intermediate (PubMed : 20026068).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : lasA
Research Areas : Others

Volume : 50 µg
Clone Number :
Aliases : dJ475B7.2 antibody; FLJ12525 antibody; FLJ30133 antibody; FLJ45274 antibody; LAS1 like (S. cerevisiae) antibody; Las1 like antibody; LAS1L antibody; LAS1L_HUMAN antibody; Protein LAS1 homolog antibody; Ribosomal biogenesis protein LAS1L antibody; RP3 475B7.2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9Y4W2
Immunogen : Recombinant Human Ribosomal biogenesis protein LAS1L protein (490-565AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Involved in the biogenesis of the 60S ribosomal subunit. Required for maturation of the 28S rRNA. Functions as a component of the Five Friends of Methylated CHTOP (5FMC) complex; the 5FMC complex is recruited to ZNF148 by methylated CHTOP, leading to desumoylation of ZNF148 and subsequent transactivation of ZNF148 target genes.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LAS1L
Research Areas : Cell biology

Volume : 50 µg
Clone Number :
Aliases : Larval cuticle protein A1A antibody; TM-LCP A1A antibody; TM-A1A antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Tenebrio molitor (Yellow mealworm beetle)
UniProt ID : P80681
Immunogen : Recombinant Tenebrio molitor Larval cuticle protein A1A protein (1-174AA)
Raised in : Rabbit
Species Reactivity : Tenebrio molitor
Tested Applications : ELISA
Background : Component of the cuticle of the larva of Tenebrio molitor.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names :
Research Areas : Others

Volume : 50 µL
Clone Number :
Aliases : cytoplasmic antibody; Cytoplasmic leucyl tRNA synthetase antibody; Cytosolic leucyl tRNA synthetase antibody; FLJ10595 antibody; FLJ21788 antibody; hr025Cl antibody; HSPC 192 antibody; HSPC192 antibody; KIAA1352 antibody; LARS 1 antibody; Lars antibody; LARS1 antibody; Leucine translase antibody; Leucine tRNA ligase antibody; Leucine--tRNA ligase antibody; Leucyl tRNA synthetase cytoplasmic antibody; Leucyl-tRNA synthetase antibody; LeuRS antibody; LEUS antibody; LRS antibody; PIG 44 antibody; PIG44 antibody; Proliferation inducing gene 44 antibody; RNTLS antibody; SYLC_HUMAN antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9P2J5
Immunogen : Recombinant Human Leucine--tRNA ligase, cytoplasmic protein (614-892AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Catalyzes the specific attachment of an amino acid to its cognate tRNA in a two step reaction : the amino acid (AA) is first activated by ATP to form AA-AMP and then transferred to the acceptor end of the tRNA. Exhibits a post-transfer editing activity to hydrolyze mischarged tRNAs.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LARS
Research Areas : Epigenetics and Nuclear Signaling

Volume : 50 µg
Clone Number :
Aliases : DKFZp564K112 antibody; HDCMA18P antibody; La related protein 7 antibody; La ribonucleoprotein domain family member 7 antibody; La ribonucleoprotein domain family member 7 antibody; La-related protein 7 antibody; LARP 7 antibody; larp7 antibody; LARP7_HUMAN antibody; MGC104360 antibody; P TEFb interaction protein for 7SK stability antibody; P-TEFb-interaction protein for 7SK stability antibody; PIP7S antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q4G0J3
Immunogen : Recombinant Human La-related protein 7 protein (409-471AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Negative transcriptional reg µLator of polymerase II genes, acting by means of the 7SK RNP system. Within the 7SK RNP complex, the positive transcription elongation factor b (P-TEFb) is sequestered in an inactive form, preventing RNA polymerase II phosphorylation and subsequent transcriptional elongation.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LARP7
Research Areas : Epigenetics and Nuclear Signaling

Volume : 50 µg
Clone Number :
Aliases : Acheron antibody; Achn antibody; FLJ11196 antibody; La ribonucleoprotein domain family member 6 antibody; La-related protein 6 antibody; LARP6 antibody; LARP6_HUMAN antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q9BRS8
Immunogen : Recombinant Human La-related protein 6 protein (294-453AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Reg µLates the coordinated translation of type I collagen alpha-1 and alpha-2 mRNAs, CO1A1 and CO1A2. Stabilizes mRNAs thro µgh high-affinity binding of a stem-loop structure in their 5\' UTR. This reg µLation requires VIM and MYH10 filaments, and the helicase DHX9.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LARP6
Research Areas : Epigenetics and Nuclear Signaling

Volume : 50 µg
Clone Number :
Aliases : LARP1B antibody; LARP2 antibody; La-related protein 1B antibody; La ribonucleoprotein domain family member 1B antibody; La ribonucleoprotein domain family member 2 antibody; La-related protein 2 antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q659C4
Immunogen : Recombinant Human La-related protein 1B protein (1-201AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background :
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LARP1B
Research Areas : Cell biology

Volume : 50 µg
Clone Number :
Aliases : LAPTM5 antibody; KIAA0085 antibody; Lysosomal-associated transmembrane protein 5 antibody; Lysosomal-associated m µLtitransmembrane protein 5 antibody; Retinoic acid-inducible E3 protein antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q13571
Immunogen : Recombinant Human Lysosomal-associated transmembrane protein 5 protein (205-262AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : May have a special functional role during embryogenesis and in ad µLt hematopoietic cells.
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, PH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LAPTM5
Research Areas : Developmental biology

Volume : 50 µg
Clone Number :
Aliases : LAPTM4B antibody; PSEC0001 antibody; Lysosomal-associated transmembrane protein 4B antibody; Lysosome-associated transmembrane protein 4-beta antibody
Product Type : polyclonal Ab Antibody
Immunogen Species : Homo sapiens (Human)
UniProt ID : Q86VI4
Immunogen : Recombinant Human Lysosomal-associated transmembrane protein 4B protein (174-226AA)
Raised in : Rabbit
Species Reactivity : Human
Tested Applications : ELISA
Background : Required for optimal lysosomal function (PubMed : 21224396). Blocks EGF-stim µLated EGFR intraluminal sorting and degradation. Conversely by binding with the phosphatidylinositol 4,5-bisphosphate, reg µLates its PIP5K1C interaction, inhibits HGS ubiquitination and relieves LAPTM4B inhibition of EGFR degradation (PubMed : 25588945). Recruits SLC3A2 and SLC7A5 (the Leu transporter) to the lysosome, promoting entry of leucine and other essential amino acid (EAA) into the lysosome, stim µLating activation of proton-transporting vacuolar (V)-ATPase protein pump (V-ATPase) and hence mTORC1 activation (PubMed : 25998567). Plays a role as negative reg µLator of TGFB1 production in reg µLatory T cells (PubMed : 26126825). Binds ceramide and facilitates its exit from late endosome in order to control cell death pathways (PubMed : 26280656).
Clonality : polyclonal Ab
Isotype : IgG
Purification Method : >95%, Protein G purified
Conj µgate : Biotin
Buffer : Preservative : 0.03% Proclin 300
Constituents : 50% Glycerol, 0.01M PBS, pH 7.4
Form : Liquid
Stroage : Upon receipt, store at -20°C or -80°C. Avoid repeated freeze.
Target Names : LAPTM4B
Research Areas : Cancer